Modular-Lab Syntheses
Modular-Lab for Ga68-DOTA-conjugated Peptides
The application of 68Ga-labelled DOTA-conjugated peptides for positron emission tomography (PET) has been widely-accepted over the last years. Especially the use of 68Ga-DOTA-conjugated peptides has become more and more interesting. It is highly specific for the visualization of somatostatin receptor positive tumour tissue and therefore important for the diagnosis of neuroendocrine tumours and metastases. The setup of Modular-Lab and Modular-Lab PharmTracer allow the fully automated synthesis of 68Ga-DOTA-conjugated peptides, starting with the direct elution of the 68Ga from the generator, to the synthesis process including solid phase extraction and down to the filtration of the final product. The Modular-Lab system can be provided with or without pre-purification.
The Modular-Lab PharmTracer gives you the possibility to additionally label 90Y, 177Lu and 111In by using easy-exchangeable one-way sterile cassettes. You can thus label different radionuclides with the same setup without having to fear cross contamination issues.
Download information on Ga68 synthesis - fractionation method
Download information on Ga68 synthesis with pre-purification
Download information on Ga68, In111, Y90 and Lu177 synthesis with Modular-Lab PharmTracer
Please visit the Gallium-68 WebPortal for more information on 68Ga-peptide labelling.
Modular-Lab for F18-FEC
18F-Fluorethylcholine is been widely used in the PET oncology for proliferation studies of prostate carcinoma over the last years. By using the Modular-Lab, the synthesis of 18F-Fluorethylcholine can be done in a fully automated as well as in a manual mode. Processing and purification has been simplified by integration of ion-exchange cartridges. Therefore, no HPLC system is needed and the small and simple setup fits into every Hot Cell.
Download F18-FEC synthesis information
Modular-Lab for F18-FDG
FDG or 18F-labelled fluorodeoxyglucose is the most common and successful radiopharmaceutical used for PET in oncology (tumour, brain and heart imaging studies). Runs can be achieved in one hot-cell without manual interference with Modular-Lab single, double and fourfold production. The cleaning procedure is characterized by a fully automatic three step system - precleaning, cleaning, and drying. Adding of further modules enables the FDG synthesis device to work as a backup system.
Download F18-FDG synthesis information
Modular-Lab for 11C labelled compounds
Carbon-11 - characterized by its relatively short half life - has the advantage to be applicable for repeated PET studies while still allowing multi-step radiosynthesis sequences. 11C methyl iodide (11C-CH3I) is the most important and frequently used secondary 11C labelling precursor. Its versatility allows the synthesis of a wide variety of PET tracers.
We are continuously trying to offer you different approaches for the synthesis of C-11 labelled compounds. Besides the wet chemistry pathway for producing 11C methyl iodide (11C-CH3I), we now offer the gas-phase approach where you can also produce 11C methyl triflate (11C-CH3OTf). The gas-phase 11C methyl iodide setup was developed and validated in close cooperation with Bruce H. Mock Ph.D., Associate Professor of Radiology at Indiana University (USA).
For certain radiopharmaceuticals other 11C based precursors are necessary requiring a different synthesis approach - heterogeneous catalysis. One precursor is 11C-CO which can be used to synthesize PET tracers which are not accessible by the application of 11C-CH3I or 11C-CO2. With the Modular-Lab CO-Converter you are now able to easily produce the 11C-CO precursor.
Download C-11 Methyl Iodide synthesis information